Tacrolimus
Tacrolimus
Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production.
For use after allogenic organ transplant to reduce the activity of the patient’s immune system and so the risk of organ rejection. It has also been used in a topical preparation in the treatment of severe atopic dermatitis.
|
Items |
Specifications |
Results |
|
Appearance |
A white crystalline powder |
Conforms |
|
Identification |
Retention time of major peak of Assay preparation corresponds to that of the chromatogram of the Standard preparation obtained as directed in the Assay |
Conforms |
|
[α] D23,.in chloroform |
-75.0 º～ - 90.0 º |
-84.0º |
|
Melting range |
122～129℃ |
125～128.0℃ |
|
Water |
≤3.0% |
1.9% |
|
Heavy Metals |
≤10ppm |
Conforms |
|
Residue on ignition |
≤0.1% |
Conforms |
|
Related substances |
Total impurities ≤2.0% |
0.5% |
|
Assay |
≥98.0% |
98.6% |
|
Items |
Specifications |
Results |
|
Appearance |
A white crystalline powder |
Conforms |
|
Identification |
Retention time of major peak of Assay preparation corresponds to that of the chromatogram of the Standard preparation obtained as directed in the Assay |
Conforms |
|
[α] D23,.in chloroform |
-75.0 º～ - 90.0 º |
-84.0º |
|
Melting range |
122～129℃ |
125～128.0℃ |
|
Water |
≤3.0% |
1.9% |
|
Heavy Metals |
≤10ppm |
Conforms |
|
Residue on ignition |
≤0.1% |
Conforms |
|
Related substances |
Total impurities ≤2.0% |
0.5% |
|
Assay |
≥98.0% |
98.6% |
Storage: in dry, cool, and shaded place with original packaging, avoid moisture, store at room temperature.
Shelf Life: 48 months
Package:in 25kg/bag
delivery:prompt
1. What’s your payment terms?
T/T or L/C.
2. What’s your delivery time?
Usually we will arrange the shipment in 7 -15 days.
3. How about the packing?
Usually we provide the packing as 25 kg / bag or carton. Of course, if you have special requirements on them, we will according to you.
4. How about the validity of the products?
According to the products you ordered.
5. What documents you provide?
Usually, we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.
6. What is loading port?
Usually is Shanghai,Qingdao or Tianjin.
